Publications in peer-reviewed scientific journals

  1. Enriched Differentiation of Human Otic Sensory Progenitor Cells Derived From Induced Pluripotent Stem Cells. Hanae Lahlou, Emmanuel Nivet, Alejandra Lopez-Juarez, Arnaud Fontbonne, Said Assou, and Azel Zine. Frontiers in Molecular Neuroscience 11 (2018). doi: 10.3389/fnmol.2018.00452
  2. Molecular characterization and prospective isolation of human fetal cochlear hair cell progenitors. Marta Roccio, Michael Perny, Megan Ealy, Hans Ruedi Widmer, Stefan Heller, and Pascal Senn. Nature Communications 9, no. 1 (2018). doi: 10.1038/s41467-018-06334-7
  3. Modeling human early otic sensory cell development with induced pluripotent stem cells. Hanae Lahlou, Alejandra Lopez-Juarez, Arnaud Fontbonne, Emmanuel Nivet, and Azel Zine. PLOS ONE 13, no. 6 (2018): e0198954. doi: 10.1371/journal.pone.0198954
  4. Expression of trans-membrane serine protease 3 (TMPRSS3) in the human organ of Corti. Wei Liu, Hubert Löwenheim, Peter A. Santi, Rudolf Glueckert, Annelies Schrott-Fischer, and Helge Rask-Andersen. Cell and Tissue Research (2018). doi: 10.1007/s00441-018-2793-2
  5. Macrophages in the Human Cochlea: Saviors or Predators—A Study Using Super-Resolution Immunohistochemistry. Wei Liu, Matyas Molnar, Carolyn Garnham, Heval Benav, and Helge Rask-Andersen. Frontiers in Immunology 9 (2018). doi: 10.3389/fimmu.2018.00223
  6. Generation of Otic Sensory Neurons from Mouse Embryonic Stem Cells in 3D Culture. Michael Perny, Ching-Chia Ting, Sonja Kleinlogel, Pascal Senn, and Marta Roccio. Frontiers in Cellular Neuroscience 11 (2017). doi: 10.3389/fncel.2017.00409
  7. Clonal Expansion of Lgr5-Positive Cells from Mammalian Cochlea and High-Purity Generation of Sensory Hair Cells. Will J. McLean, Xiaolei Yin, Lin Lu, Danielle R. Lenz, Dalton McLean, Robert Langer, Jeffrey M. Karp, and Albert S.B. Edge. Cell Reports 18, no. 8 (2017): 1917-1929. doi: 10.1016/j.celrep.2017.01.066
  8. Role of BDNF and neurotrophic receptors in human inner ear development. L. Johnson Chacko, M. J. F. Blumer, E. Pechriggl, H. Rask-Andersen, W. Dietl, A. Haim, H. Fritsch, R. Glueckert, J. Dudas, and A. Schrott-Fischer. Cell and Tissue Research 370, no. 3 (2017): 347-363. doi: 10.1007%2Fs00441-017-2686-9
  9. The Human “Cochlear Battery” – Claudin-11 Barrier and Ion Transport Proteins in the Lateral Wall of the Cochlea. Wei Liu, Annelies Schrott-Fischer, Rudolf Glueckert, Heval Benav, and Helge Rask-Andersen. Frontiers in Molecular Neuroscience 10 (2017). doi: 10.3389/fnmol.2017.00239
  10. Molecular composition and distribution of gap junctions in the sensory epithelium of the human cochlea—a super-resolution structured illumination microscopy (SR-SIM) study. Wei Liu, Hao Li, Fredrik Edin, Johan Brännström, Rudolf Glueckert, Annelies Schrott-Fischer, Matyas Molnar, Dirk Pacholsky, Kristian Pfaller, and Helge Rask-Andersen. Upsala Journal of Medical Sciences 122, no. 3 (2017): 160-170. doi: 10.1080/03009734.2017.1322645
  11. Supernumerary human hair cells—signs of regeneration or impaired development? A field emission scanning electron microscopy study. Helge Rask-Andersen, Hao Li, Hubert Löwenheim, Marcus Müller, Kristian Pfaller, Annelies Schrott-Fischer, and Rudolf Glueckert. Upsala Journal of Medical Sciences 122, no. 1 (2017): 11-19. doi: 10.1080/03009734.2016.1271843
  12. Streptococcus pneumonia e -induced ototoxicity in organ of Corti explant cultures. Michael Perny, Magdalena Solyga, Denis Grandgirard, Marta Roccio, Stephen L. Leib, and Pascal Senn. Hearing Research 350 (2017): 100-109. doi: 10.1016/j.heares.2017.04.012
  13. Neurosensory Differentiation and Innervation Patterning in the Human Fetal Vestibular End Organs between the Gestational Weeks 8–12. Lejo Johnson Chacko, Elisabeth J. Pechriggl, Helga Fritsch, Helge Rask-Andersen, Michael J. F. Blumer, Anneliese Schrott-Fischer, and Rudolf Glueckert. Frontiers in Neuroanatomy 10 (2016). doi: 10.3389/fnana.2016.00111
  14. The effect of pulsed electric fields on the electrotactic migration of human neural progenitor cells through the involvement of intracellular calcium signaling. Hisamitsu Hayashi, Fredrik Edin, Hao Li, Wei Liu, and Helge Rask-Andersen. Brain Research 1652 (2016): 195-203. doi: 10.1016/j.brainres.2016.09.043
  15. Distinct capacity for differentiation to inner ear cell types by progenitor cells of the cochlea and vestibular organs. Will J. McLean, Dalton T. McLean, Ruth Anne Eatock, and Albert S. B. Edge. Development. (2016): dev.139840. doi: 10.1242/dev.139840
  16. Single-cell analysis delineates a trajectory toward the human early otic lineage. Megan Ealy, Daniel C. Ellwanger, Nina Kosaric, Andres P. Stapper, and Stefan Heller. Proceedings of the National Academy of Sciences 113, no. 30 (2016): 8508-8513. doi: 10.1073/pnas.1605537113
  17. The Severity of Infection Determines the Localization of Damage and Extent of Sensorineural Hearing Loss in Experimental Pneumococcal Meningitis. M. Perny, M. Roccio, D. Grandgirard, M. Solyga, P. Senn, and S. L. Leib. Journal of Neuroscience 36, no. 29 (2016): 7740-7749. doi: 10.1523/JNEUROSCI.0554-16.2016
  18. Scanning Electron Microscopic Examination of the Extracellular Matrix in the Decellularized Mouse and Human Cochlea. Peter A. Santi, Robair Aldaya, Alec Brown, Shane Johnson, Tyler Stromback, Sebahattin Cureoglu, and Helge Rask-Andersen. JARO 17, no. 3 (2016): 159-171. doi: 10.1007/s10162-016-0562-z , public repository:
  19. Sox2 in the differentiation of cochlear progenitor cells. Judith S. Kempfle, Jack L. Turban, and Albert S. B. Edge. Sci Rep 6 (2016): 23293. doi: 10.1038/srep23293
  20. Strategy towards independent electrical stimulation from cochlear implants: Guided auditory neuron growth on topographically modified nanocrystalline diamond. Yixiao Cai, Fredrik Edin, Zhe Jin, Andrei Alexsson, Olafur Gudjonsson, Wei Liu, Helge Rask-Andersen, Mikael Karlsson, and Hao Li. Acta Biomaterialia 31 (2016): 211-220. doi: 10.1016/j.actbio.2015.11.021
  21. 3D computational reconstruction of tissues with hollow spherical morphologies using single-cell gene expression data. Robert Durruthy-Durruthy, Assaf Gottlieb, and Stefan Heller. Nat Protoc 10, no. 3 (2015): 459-474. doi: 10.1038/nprot.2015.022 , public repository:
  22. Cell cycle reactivation of cochlear progenitor cells in neonatal FUCCI mice by a GSK3 small molecule inhibitor. M. Roccio, S. Hahnewald, M. Perny, and P. Senn. Sci Rep 5 (2015): 17886. doi: 10.1038/srep17886
  23. Inner Ear Hair Cell-Like Cells from Human Embryonic Stem Cells. Mohammad Ronaghi, Marjan Nasr, Megan Ealy, Robert Durruthy-Durruthy, Joerg Waldhaus, Giovanni H. Diaz, Lydia-Marie Joubert, Kazuo Oshima, and Stefan Heller. Stem Cells and Development 23, no. 11 (2014): 1275-1284. doi: 10.1089/scd.2014.0033 , public repository:

Other public documents

  1. Project leaflet. This leaflet explains the general OTOSTEM concept. Download the leaflet
  2. 1st Publishable Summary. A summary of the achievements of the first 18 months. Download the 1st publishable summary
  3. 2nd Publishable Summary. A summary of the achievements up to October 2016 (project month 36). Download the 2nd publishable summary
  4. 3rd Publishable Summary. A summary of the achievements up to the end of the project in October 2017 (project month 48). Download the 3rd publishable summary
  5. Final Publishable Summary. An extended summary of the project activities. Download the final publishable summary

The OTOSTEM project has received funding from the European Community's Seventh Framework Programme under grant agreement No. 603029.